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Tuesday, June 4, 2013

The Effects of Stimulation Parameters on Clinical Outcomes in Patients With Vagus Nerve Stimulation Implants With Major Depression.

2013 May 30. [Epub ahead of print]

The Effects of Stimulation Parameters on Clinical Outcomes in Patients With Vagus Nerve Stimulation Implants With Major Depression.

Source

From the Department of Psychiatry and Psychotherapy, Friedrich-Alexander University Erlangen-Nürnberg.

Abstract

Stimulation techniques, such as vagus nerve stimulation, are a promising new approach for treatment-resistant depression. Most international studies have used fixed stimulation parameters or have varied the stimulation frequencies. Our retrospective examination of 2 parallel groups of 10 patients each compared low-strength/high-frequency vagus nerve stimulation parameters (≤1.5 mA, 20 Hz) with high-strength/low-frequency (>1.5 mA, 15 Hz) parameters. We found a significant decrease in the Hamilton Rating Scale for Depression scores in patients who were treated using the low-strength/high-frequency stimulation parameters. In contrast, the scores of the patients treated with high-strength/low-frequency stimulation did not change.
PMID:
23728236
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23728236

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