Neurostimulation-past, present, and beyond.

Source

Institution of Clinical Neuroscience and Physiology, Sahlgrenska Academy, Göteborgs University, 413 45 Göteborg, Sweden, ebm@neuor.gu.se.

Abstract

Neurostimulation as a treatment for epilepsy has been around for almost 20 years in the form of vagus nerve stimulation. Newer types of neurostimulation are being developed and stand on the brink of approval for use. The two newest therapies, not yet approved in the United States, are deep brain stimulation and the Responsive Neurostimulator System . In fact, in Europe, approval has already been given for deep brain stimulation and newer forms of vagus nerve stimulation. Efficacy is similar between these therapies, and side effects are moderate, so what will be the future? The challenge will be to learn how to use these therapies correctly and offer the right treatment for the right patient.

PMID:: 23118604; [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/23118604

Related citations in PubMed

Review Neurostimulation: vagus nerve stimulation and beyond.[Semin Pediatr Neurol. 2011]
Neurostimulation for epilepsy.[Handb Clin Neurol. 2012]
[Newer treatment of epilepsy--brain pacemakers and transcranial magnetic stimulation].[Rinsho Shinkeigaku. 2005]
Review Neurostimulation therapies for treatment resistant depression: a focus on vagus nerve stimulation and deep brain stimulation.[Int Rev Psychiatry. 2011]
Neurostimulation for the Treatment of Epilepsy: A Review of Current Surgical Interventions.[Neuromodulation. 2012]

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Wednesday, March 7, 2012

Comparison of seizure control outcomes and the safety of vagus nerve, thalamic deep brain, and responsive neurostimulation: evidence from randomized controlled trials.

Neurosurg Focus. 2012 Mar;32(3):E14.

Comparison of seizure control outcomes and the safety of vagus nerve, thalamic deep brain, and responsive neurostimulation: evidence from randomized controlled trials.

Rolston JD, Englot DJ, Wang DD, Shih T, Chang EF.

Source

Departments of Neurological Surgery and.

Abstract

Epilepsy is a devastating disease, often refractory to medication and not amenable to resective surgery. For patients whose seizures continue despite the best medical and surgical therapy, 3 stimulation-based therapies have demonstrated positive results in prospective randomized trials: vagus nerve stimulation, deep brain stimulation of the thalamic anterior nucleus, and responsive neurostimulation. All 3 neuromodulatory therapies offer significant reductions in seizure frequency for patients with partial epilepsy. A direct comparison of trial results, however, reveals important differences among outcomes and surgical risk between devices. The authors review published results from these pivotal trials and highlight important differences between the trials and devices and their application in clinical use.

PMID:: 22380855; [PubMed - in process]

http://www.ncbi.nlm.nih.gov/pubmed/22380855