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Friday, July 20, 2012

110 Modulation of the inflammatory response: a potential novel use for vagus nerve stimulation.

2012 Aug;71(2):E546.

110 Modulation of the inflammatory response: a potential novel use for vagus nerve stimulation.



: The neural modulation of the immune response is thought to be mediated, in part, through the vagus nerve. Prior studies in experimental animals have shown vagus nerve stimulation to modulate cytokines response to inducers of inflammation. Tumor necrosis factor (TNF) is a cytokine that is known to play an important role in the pathophysiology of sepsis and other inflammatory disorders. The production of TNF in response to endotoxin challenge can be used as an index of the magnitude of the inflammatory response. We studied 7 patients who underwent vagus nerve stimulation for epilepsy to investigate for changes in TNF induction and this response over time.


: We conducted a prospective clinical study recruiting patients with intractable epilepsy who underwent vagus nerve stimulator implantation. Peripheral whole blood was drawn on the day of surgery at four time points peri-operatively (timed before and after intraoperative stimulation): 1. prior to anesthesia, 2. after anesthetic induction and anterior cervical dissection, 3. after vagal nerve stimulation in situ, and 4. four hours after vagal nerve stimulation. On each follow-up clinical visit a before and after vagus nerve stimulation blood draw was obtained. Whole blood samples were stimulated with endotoxin lipopolysaccharide concentrations 0.1, 1, and 10 ng/mL ex vivo. TNF responses were recorded.


: Seven epileptic patients consented to the study (male = 4, female = 3). Four patients (4/7 [57%]) demonstrated TNF response suppression after direct vagus nerve stimulation intraoperatively. We found 4/5 [80%] patients (2 patients without follow-up) with serial follow-up visits to sustain chronic suppression of inflammatory responses. No patients experienced intraoperative complications or developed adverse events from serial phlebotomy.


: Results here support the theory of a direct link between the brain and systemic inflammation via the vagus nerve in humans. This paves the way for the use of vagus nerve stimulation as treatment for inflammatory disorders.
[PubMed - in process]

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