J ECT. 2013 Jan 8. [Epub ahead of print]
Vagus Nerve Stimulation in Treatment-Resistant Depression: Acute and Follow-Up Results of an Italian Case Series.
Source
From the Departments of *Psychiatry and †Mental Health, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, University of Milan, Milan, Italy.Abstract
ABSTRACT: The present study evaluated short- and long-term efficacy and tolerability of augmentative vagus nerve stimulation (VNS) in a group of patients with treatment-resistant depression (N = 6). A statistically significant improvement in the Hamilton Depression Rating Scale (HDRS21) and Montgomery-Asberg Depression Rating Scale after 3 months (P = 0.039 and P = 0.05, respectively) was found in comparison with baseline (VNS implant). After 12 months, a statistically significant improvement was observed in the Hamilton Depression Rating Scale (HDRS21), Montgomery-Asberg Depression Rating Scale, and Clinical Global Impression (P = 0.01, P = 0.005, and P = 0.001, respectively). Patients showed an overall favorable tolerability. Present data support VNS short- and long-term efficacy and tolerability in a small group of patients with treatment-resistant depression. Further controlled investigation is necessary to confirm the present open findings.- PMID:
- 23303420
- [PubMed - as supplied by publisher]
Related citations in PubMed
- A pilot study of vagus nerve stimulation (VNS) for treatment-resistant anxiety disorders.[Brain Stimul. 2008]
- A 1-year pilot study of vagus nerve stimulation in treatment-resistant rapid-cycling bipolar disorder.[J Clin Psychiatry. 2008]
- Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study.[Biol Psychiatry. 2005]Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study.Rush AJ, Sackeim HA, Marangell LB, George MS, Brannan SK, Davis SM, Lavori P, Howland R, Kling MA, Rittberg B, et al. Biol Psychiatry. 2005 Sep 1; 58(5):355-63.
- Review Safety and efficacy of Vagus Nerve Stimulation in treatment-resistant depression. A systematic review.[J Affect Disord. 2008]
- Review Vagus nerve stimulation in depression.[Expert Opin Pharmacother. 2001]
No comments:
Post a Comment